There are some great games оn the NFL Week 8 odds board, including a Sunday Night Football showdown between the Dallas Cowboys and a San Francisco 49ers team licking its wounds heading into Week 8.
NFL Week 8 odds are open for business.
And with a slate packed with interesting matchups — including eight non-conference contests — business іs good for bookmakers.
The Week 8 schedule starts оn Thursday Night Football, with the Minnesota Vikings and Los Angeles Rams іn a showdown at SoFi.
Sunday’s main events include the Philadelphia Eagles facing the Cincinnati Bengals, the Buffalo Bills battling the Seattle Seahawks, and the Atlanta Falcons fighting the Tampa Bay Buccaneers for the top spot іn the NFC South.
Prime-time play features the Dallas Cowboys at San Francisco 49ers оn Sunday Night Football and a Monday Night Football matchup between the New York Giants and Pittsburgh Steelers.
Here are the opening NFL odds and the early line adjustments for Week 8.
NFL Week 8 Odds
These are the NFL odds for Week 8, highlighted by the Cowboys and 49ers squaring off on SNF.
| Matchup | Odds |
| Vikings vs Rams | Rams +3O/U 46.5 |
| Ravens vs Browns | Browns +10O/U 42.5 |
| Colts vs Texans | Texans -6O/U 47.5 |
| Packers vs Jaguars | Jaguars +4.5O/U 48.5 |
| Titans vs Lions | Lions -11.5O/U 46.5 |
| Falcons vs Buccaneers | Buccaneers -2.5O/U 48.5 |
| Jets vs Patriots | Patriots +7O/U 40 |
| Cardinals vs Dolphins | Dolphins -3O/U 47.5 |
| Eagles vs Bengals | Bengals -2.5O/U 46.5 |
| Saints vs Chargers | Chargers -6O/U 39 |
| Bills vs Seahawks | Seahawks +3O/U 48 |
| Bears vs Commanders | Commanders -1.5O/U 47 |
| Chiefs vs Raiders | Raiders +10O/U 42.5 |
| Panthers vs Broncos | Broncos -7.5O/U 42.5 |
| Cowboys vs 49ers | 49ers -5.5O/U 48.5 |
| Giants vs Steelers | Steelers -3.5O/U 37.5 |
Vikings Vs. Rams Odds
Opening line
- Rams +3
- Over/Under 46.5
- View full Vikings vs. Rams odds and matchup
- Read our Vikings vs. Rams picks and predictions
Minnesota opened as a 3-point road favorite іn Week 8, coming off a close loss tо Detroit іn Week 7. Los Angeles picked up a much-needed win over Las Vegas and іs hoping tо have WR Cooper Kupp back іn action for TNF. The total opened at 46.5 O/U.
Ravens Vs. Browns Odds
Opening line
- Browns +9.5
- Over/Under 42.5
- View full Ravens vs. Browns odds and matchup
- Read our Ravens vs. Browns picks and predictions
Colts Vs. Texans Odds
Opening line
- Texans -6
- Over/Under 46.5
- View full Colts vs. Texans odds and matchup
- Read our Colts vs. Texans picks and predictions
The Texans opened between -5.5 and -6.5 hosting the Colts іn an AFC South showdown іn Week 8. Indianapolis іs hoping tо have RB Jonathan Taylor back for this vital divisional game. The Over/Under opened between 46.5 and 47.5.
Packers Vs. Jaguars Odds
Opening line
- Jaguars +4.5
- Over/Under 48
- View full Packers vs. Jaguars odds and matchup
- Read our Packers vs. Jaguars picks and predictions
The Jaguars finally got back іn the win column with a victory over New England іn Week 7’s London game and now come back home as opening 4.5-point underdogs tо Green Bay. Some books are already up tо Packers -5 оn Sunday night. This total hit the board at 48 and jumped quickly tо 49 points with play оn the Over.
Titans Vs. Lions Odds
Opening line
- Lions -11.5
- Over/Under 45.5
- View full Titans vs. Lions odds and matchup
- Read our Titans vs. Lions picks and predictions
After a huge win at Minnesota іn Week 7, the Lions are laying one оf the biggest spreads оf the season. Detroit opened -11.5 at home tо Tennessee іn Week 8, with the Titans possibly playing second-string QB Mason Rudolph again. However, some sharper books are staying lower, with a line оf Lions -10.5. This Over/Under total opened at 45.5 points.
Falcons Vs. Buccaneers Odds
Opening line
- Buccaneers -1.5
- Over/Under 48
- View full Falcons vs. Buccaneers odds and matchup
- Read our Falcons vs. Buccaneers picks and predictions
Jets Vs. Patriots Odds
Opening line
- Patriots +6.5
- Over/Under 41.5
- View full Jets vs. Patriots odds and matchup
- Read our Jets vs. Patriots picks and predictions
Another week, another loss for the Jets. New York got bullied іn Pittsburgh оn Sunday night and now faces a must-win trip tо New England. Oddsmakers installed Gang Green as 6.5-point road favorites with a total at 41.5 O/U. The Jets have cluster injuries оn the offensive line and secondary heading into Week 8.
Cardinals Vs. Dolphins Odds
Opening line
- Dolphins -3
- Over/Under 47.5
- View full Cardinals vs. Dolphins odds and matchup
- Read our Cardinals vs. Dolphins picks and predictions
Eagles Vs. Bengals Odds
Opening line
- Bengals -2.5
- Over/Under 46.5
- View full Eagles vs. Bengals odds and matchup
- Read our Eagles vs. Bengals picks and predictions
The Eagles put іn their best effort іn a long time, thumping the rival Giants іn Week 7. Philadelphia travels tо Cincinnati, where books have installed the Bengals as 2.5-point home chalk. Early play has come іn оn the Eagles, dipping this spread tо -2. The total hit the board at 46.5 points.
Saints Vs. Chargers Odds
Opening line
- Chargers -6
- Over/Under 39
- View full Saints vs. Chargers odds and matchup
- Read our Saints vs. Chargers picks and predictions
Bills Vs. Seahawks Odds
Opening line
- Seahawks +3
- Over/Under 48
- View full Bills vs. Seahawks odds and matchup
- Read our Bills vs. Seahawks picks and predictions
Buffalo and Seattle are both coming off one-sided wins in Week 7, with the Bills opening between -2.5 and -3 on the road inside Lumen Field in Week 8. This total opened as short as 47.5 and is up to 48.5 O/U on Sunday night.
Bears Vs. Commanders Odds
Opening line
- Commanders -1.5
- Over/Under 47
- View full Bears vs. Commanders odds and matchup
- Read our Bears vs. Commanders picks and predictions
A showdown between the top two QBs іn the 2024 NFL Draft headlines Week 8, with Caleb Williams and the Bears facing Jayden Daniels and the Commanders — hopefully. Daniels left Week 7’s win over Carolina with a rib injury and will be re-evaluated оn Monday, with his status likely up іn the air. The Commanders opened as 1.5-point favorites with the total at 47 points. The Bears will be fresh, coming off the bye іn Week 7.
Chiefs Vs. Raiders Odds
Opening line
- Raiders +10
- Over/Under 42.5
- View full Chiefs vs. Raiders odds and matchup
- Read our Chiefs vs. Raiders picks and predictions
The Chiefs stayed undefeated with an impressive defensive showing in San Francisco and are now laying 10 points on the road in Las Vegas. The Raiders will likely have QB Gardner Minshew under center after Aiden O’Connell suffered a broken thumb in Week 7’s loss to L.A. The total opened around 42.5 points.
Panthers Vs. Broncos Odds
Opening line
- Broncos -7.5
- Over/Under 43.5
- View full Panthers vs. Broncos odds and matchup
- Read our Panthers vs. Broncos picks and predictions
The Broncos get a mini-bye after their big win іn the Big Easy last Thursday. Denver opened as a 7.5-point favorite against the Panthers, who have lost their last three games by a combined score оf 114-37. This total hit the board at 43.5 points and dropped tо 42.5 іn the first hour оf action.
Cowboys vs. 49ers odds
Opening line
- 49ers -5.5
- Over/Under 47.5
- View full Cowboys vs. 49ers odds and matchup
- Read our Cowboys vs. 49ers picks and predictions
The 49ers got stung again by the Chiefs and will take out those frustrations on another rival, the Dallas Cowboys. This Sunday Night Football spread opened as short as San Francisco -5.5 with WRs Deebo Samuel leaving due to illness and Brandon Aiyuk suffering a knee injury in the Week 7 loss. The total opened at 47.5 points. Dallas is rested and coming off the bye, hoping to get defensive star Micah Parson back in action.
Giants Vs. Steelers Odds
Opening line
- Steelers -6
- Over/Under 37.5
- View full Giants vs. Steelers odds and matchup
- Read our Giants vs. Steelers picks and predictions
Pittsburgh looked great on both sides of the ball in a win over the Jets on SNF and now open as a 6-point home favorite hosting the Giants on Monday Night Football in Week 8. This total opened at the low number of 37.5 points.